Having been drawn in the same half as his long-time rival Rafael Nadal, who is making his return from a left foot injury that forced him to end his 2021 season early, Djokovic could face his fellow 20-time Major champion in the semi-final.
Alexander Zverev is another potential semi-final opponent, and the world No 3 will be vying to defeat Djokovic at Grand Slam level after overcoming the 34-year-old at both the Tokyo Olympics and ATP Finals last year, before going on to win both prestigious titles.
But if Djokovic can overcome his last-four opponent and make a 10th Australian Open final appearance, it will likely be second seed Daniil Medvedev facing him for the title.
The world No 1 will relish the opportunity to get revenge over the Russian after losing his chance to complete the Calendar Grand Slam last year when Medvedev defeated him in straight sets in the US Open final.
But the world No 2 will also take a potential final clash as a grudge match – having lost last year’s Australian Open final to Djokovic.
Stefanos Tsitsipas would be another potential final opponent, and himself would want to get revenge over Djokovic after going two-sets-up on the Serb in last year’s French Open final before losing in five.