Marcus Rashford is fit to start up front for the hosts – he will be in a front three with Daniel James and Mason Greenwood. Rashford is one of four changes from the 1-1 draw against AC Milan, with Victor Lindelöf, Luke Shaw and Fred also coming into the side.
Man Utd: Henderson, Wan-Bissaka, Lindelöf, Maguire, Shaw, McTominay, Fred, Greenwood, Bruno Fernandes, James, Rashford. Subs: Bailly, Grant, Diallo, Alex Telles, Bishop, Matic, Williams, Tuanzebe, Shoretire.
Mark Noble starts in midfield for West Ham – with Jarrod Bowen and Ben Johnson also coming into David Moyes’s starting lineup:
West Ham: Fabianski, Coufal, Dawson, Diop, Cresswell, Soucek, Rice, Johnson, Noble, Bowen, Antonio. Subs: Balbuena, Benrahma, Lanzini, Alves, Martin, Trott, Odubeko, Coventry.
Referee: Chris Kavanagh (Lancashire)