That would be an interesting twist, because while Homecoming and Far From Home referred to Peter Parker’s personal journeys, Spider-Man: No Way Home would reference how these villains have been plucked from their realities and thrown into a foreign one. But why would all these villains not be able to go back to their original universes? If they were taken to the MCU, surely there’s a way they can go back home, be it through scientific or magical means, right? Not necessarily, as there’s a rumor making the rounds that all these villains have been transported to the MCU right before they die in their original universes. So if they were to go back home, they’d instantly perish.